is a 2004 Japanese animated post-apocalyptic action film directed by Shinji Aramaki and based on the Appleseed manga created by Masamune Shirow. The voice cast includes Ai Kobayashi, Jūrōta Kosugi, Mami Koyama, Yuki Matsuoka, and Toshiyuki Morikawa. The film, the second adaptation of the manga after the 1988 OVA, tells the story of Deunan Knute, a former soldier, who searches for data that can restore the reproductive capabilities of bioroids, a race of genetically engineered clones. Although it shares characters and settings with the original manga, this film's storyline is a re-interpretation, not a direct adaptation. It was released on April 18, 2004.

Plot

Deunan Knute, a young soldier and one of the Global War's last survivors, is rescued by Hitomi, a Second Generation Bioroid. Knute's escape attempt is stopped by her former lover Briareos Hecatonchires, now a cyborg. She realizes that the war had ended and she is in a Technocratic Utopian city called Olympus. Its population is half-human and half-clone, a genetically-engineered species called Bioroids. Olympus is governed by three factions: Prime Minister Athena Areios; General Edward Uranus III, head of the Olympus Army; and a Council of Elders. Everything in the city is observed and administered by an synthetic technocrat named Gaia from a building called Tartaros. While there, Deunan joins the counter-terrorism organization ESWAT.