is a 2004 Japanese animated post-apocalyptic science fiction film directed by Shinji Aramaki and based on the Appleseed manga created by Masamune Shirow. It features the voice acting of Ai Kobayashi, Jūrōta Kosugi, Mami Koyama, Yuki Matsuoka, and Toshiyuki Morikawa. The film tells the story of Deunan Knute, a former soldier, who searches for data that can restore the reproductive capabilities of bioroids, a race of genetically engineered clones. Although it shares characters and settings with the original manga, this film's storyline is a re-interpretation, not a true adaptation. This Appleseed film should not be confused with the 1988 OVA which was also inspired by the manga. Appleseed was released on April 18, 2004.
Deunan Knute, a young soldier and one of the Global War's last survivors, is rescued by Hitomi, a Second Generation Bioroid. Knute's escape attempt is stopped by her former lover Briareos Hecatonchires, now a cyborg. She realizes that the war had ended and she is in a Utopian city called Olympus. Its population is half-human and half-clone, a genetically-engineered species called Bioroids. Olympus is governed by three factions: Prime Minister Athena Areios; General Edward Uranus III, head of the Olympus Army; and a Council of Elders. Everything in the city is observed by an artificial intelligence named Gaia from a building called Tartaros. While there, Deunan joins the counter-terrorism organization ESWAT.