D.O.A. is a 1950 American film noir directed by Rudolph Maté, starring Edmond O'Brien and Pamela Britton. It is considered a classic of the genre. A fatally poisoned man tries to find out who has poisoned him and why. It was the film debuts of Beverly Garland (as Beverly Campbell) and Laurette Luez. In 2004, D.O.A. was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically significant."

Plot

An opening sequence features Frank Bigelow walking through the long hallway of a police station to report his own murder. From here to the end, the story is told in flashback. Bigelow is a hard-driving accountant and notary public in Banning, California, who decides to escape for a fun vacation in San Francisco. At the hotel, he is invited to join a group of conventioneers for a night out. He ends up at a nightclub, where unnoticed, a stranger swaps his drink for another one. The next morning, he feels extremely ill. Doctors determine that he had ingested poison, a "luminous toxin", for which no antidote is known.