D.O.A. is a 1950 American film noir directed by Rudolph Maté, starring Edmond O'Brien and Pamela Britton. It is considered a classic of the genre. A fatally poisoned man tries to find out who has poisoned him and why. It was the film debuts of Beverly Garland (as Beverly Campbell) and Laurette Luez.


An opening sequence features Frank Bigelow walking through the long hallway of a police station to report his own murder. From here to the end, the story is told in flashback. Bigelow is a hard-driving accountant and notary public in Banning, California, who decides to escape for a fun vacation in San Francisco. At the hotel, he is invited to join a group of conventioneers for a night out. He ends up at a nightclub, where unnoticed, a stranger swaps his drink for another one. The next morning, he feels extremely ill. Doctors determine that he swallowed a poison, "luminous toxin", for which no antidote is known.