A.P. Bio is an American comedy television series that premiered on February 1, 2018, on NBC as a mid-season replacement. It aired on NBC for two seasons until June 13, 2019, and moved to Peacock for its subsequent seasons. The series is focused on the everyday lives of the faculty and students of the fictitious Whitlock High School. Mike O'Brien created the series and is a recurring writer. O'Brien is also one of the executive producers alongside Seth Meyers, Lorne Michaels, Andrew Singer, and Michael Shoemaker. Although set in Toledo, Ohio, it is primarily filmed in Los Angeles, California.
When disgraced Harvard philosophy professor Jack Griffin (Glenn Howerton) loses his dream job to his rival Miles Leonard (Tom Bennett), he is forced to return to his hometown of Toledo, Ohio, to work as an advanced placement biology teacher at Whitlock High School and live in his late mother's home. He makes it clear to his class that he will not be teaching them any biology. Realizing he has a room full of honor-roll students at his disposal, he decides to use them to get revenge on Miles. Eager to prove that he is still king of the castle, Principal Durbin (Patton Oswalt) struggles to keep Jack under control. In the second season, Jack uses his students to find out how the people of Toledo find happiness in their daily lives, to gather information for what he believes will be a bestselling book.