A.P. Bio is an American comedy television series created by Mike O'Brien for NBC. The series premiered on February 1, 2018 for a special preview and made its official debut on March 1, 2018. NBC released the first three episodes on NBCUniversal streaming platforms after the February 1 broadcast premiere for early viewing.
When disgraced Harvard philosophy professor Jack Carson Griffin (Glenn Howerton) loses out on his dream job to his rival Miles Leonard (Tom Bennett), he is forced to return to Toledo, Ohio and work as an advanced placement biology teacher at the fictional Whitlock High School. Jack makes it clear to his class that he will not be teaching any biology. Realising he has a room full of honor-roll students at his disposal, Jack decides to use them for his own benefit: getting revenge on Miles. Eager to prove that he is still king of the castle, Principal Durbin (Patton Oswalt) struggles to keep Griffin under control. In its second season, Jack uses his students to find out how the people of Toledo find happiness in their daily routine, so as to mine information for what he believes will be a best-selling book.