The Big Empty is a 2003 comedy film directed and written by Steve Anderson. It stars Jon Favreau as a struggling actor with a bizarre request from his neighbor to deliver a suitcase that he cannot open. While there, he meets an unusual cast of characters, and starts to think this delivery might be more than it seems.

Plot

John Person (his stage name) is an out-of-work actor living in Los Angeles, with credit card debt of almost $28,000. Across the hall from him lives his friend, Grace. One night, his nebbish neighbor Neely, who wears a neck brace, invades his apartment with an unusual request: deliver a large blue suitcase to the truck stop of Baker, California, where it will be picked up by a man named "Cowboy", for which he will be given $25,000. John is also given a gun to defend against anyone taking the case. He initially refuses and thinks the plan is insane, but Neely has a file containing much of John's personal information, including masturbation preferences and sperm sample test results. Realizing that Neely is serious, John takes the job, but demands that he be given $28,000 to pay off his debts. Neely agrees, and John drives to Baker.