Once Again is a 2016 Philippine television drama romance fantasy series broadcast by GMA Network. Directed by Don Michael Perez, it stars Janine Gutierrez and Aljur Abrenica. It premiered on May 2, 2016 on the network's Telebabad line up replacing That's My Amboy. The series concluded on July 22, 2016 with a total of 59 episodes. It was replaced by Descendants of the Sun in its timeslot.
Reign and Edgar loves each other. However, Reign's family will arrange her marriage to Lukas. As Edgar and Reign fight their way through the tussle, the two lovers lose their lives because of Lukas. They will meet each other again after twenty years in a different time and place as two different people as Des and Aldrin with the same love for each other.