Resident Evil: Afterlife is a 2010 action horror film written and directed by Paul W. S. Anderson. It is the second film in the series that he directed, after the first film. A direct sequel to Resident Evil: Extinction (2007), it is the fourth installment in the Resident Evil film series, which is loosely based on the video game series of the same name, and the first to be shot in 3D. It stars Milla Jovovich, Ali Larter, Kim Coates, Shawn Roberts, Spencer Locke, Boris Kodjoe, and Wentworth Miller.

Plot

Alice and her clones lead the assault on Umbrella HQ, in Tokyo, slaying the entire branch except for Albert Wesker, who escapes in a tiltrotor plane and detonates a bomb that leaves a massive sinkhole. The real Alice boarded beforehand and attempted to execute Wesker, only for him to inject her with an anti-virus to remove her superhuman abilities. Wesker is revealed to have used the T-virus to gain his own superhuman abilities and prepares to kill Alice before the plane crashes into the mountains.