Resident Evil: Afterlife is a 2010 action horror film written and directed by Paul W. S. Anderson. The film marks Anderson's return to direct in the Resident Evil film series, after the first film. A direct sequel to Resident Evil: Extinction (2007), it is the fourth installment in the Resident Evil film series, which is loosely based on the video game series of the same name, and the first to be shot in 3D. It stars Milla Jovovich, Ali Larter, Kim Coates, Shawn Roberts, Spencer Locke, Boris Kodjoe, and Wentworth Miller.

Plot

One year after the events of Extinction, Alice (Milla Jovovich) and her clones lead the assault to attack Umbrella HQ, located in Tokyo, slaying the entire branch except for Albert Wesker (Shawn Roberts), who escapes in a tiltrotor plane and detonates a bomb that leaves a massive sinkhole. The real Alice boarded beforehand and attempts to execute Wesker, only for him to inject her with an anti-virus to remove her superhuman abilities. Wesker is revealed to have used the T-Virus to gain his own superhuman abilities and prepares to kill Alice before the autopilot crashes the plane into the mountains, and only Alice survives.