The Human Centipede (First Sequence) is a 2009 Dutch independent body horror film written, directed and co-produced by Tom Six. The film concerns a deranged German surgeon who kidnaps three tourists and conjoins them surgically, mouth to anus, forming the eponymous "human centipede". It stars Dieter Laser as Josef Heiter, the creator of the centipede; and Ashley C. Williams, Ashlynn Yennie, and Akihiro Kitamura as Heiter's victims.

Plot

Lindsay and Jenny, tourists from New York visiting Germany, get a flat tire on their way to a night club and seek help at the house of misanthropic, psychopathic surgeon Dr. Josef Heiter. He drugs the women with Rohypnol and kidnaps them to a makeshift medical ward. Heiter kills a kidnapped truck driver after Heiter informs him he is "not a match". Heiter also abducts Japanese tourist Katsuro. Heiter is a retired world-renowned expert at separating Siamese twins, but dreams of making new creatures by sewing humans together. He says he will surgically connect his three victims mouth-to-anus, so that they share a single digestive system. His prior experiment, the 3Dog, conjoined three Rottweilers into a "Siamese triplet"; all three dogs died following the operation. Heiter has moved on to using human subjects.