Miss Sherlock (ミス・シャーロック) is a female-led adaptation of Sir Arthur Conan Doyle's Sherlock Holmes detective stories. The show is primarily set in Tokyo, Japan. It is a co-production between HBO Asia and Hulu Japan. Both the main characters, based on Sherlock Holmes and Dr. John Watson, are played by women, Yuko Takeuchi and Shihori Kanjiya respectively and it is the first major series to cast a woman as Holmes-like detective.
Miss Sherlock depicts "consulting detective" Sara "Sherlock" Shelly Futaba (Yūko Takeuchi) solving various mysteries in modern-day Tokyo. Sherlock is assisted by her flatmate, Dr. Wato Tachibana (Shihori Kanjiya), a doctor who has recently returned from volunteering medical aid in Syria. Because of Sherlock's keen observational and deduction skills, she is frequently asked by Inspector Gentaro Reimon of the Metropolitan Police to help with cases.