Losing Isaiah is a 1995 American drama film starring Jessica Lange and Halle Berry, directed by Stephen Gyllenhaal. It is based on the novel of the same name by Seth Margolis. The screenplay is written by Naomi Foner Gyllenhaal. The original music score is composed by Mark Isham.

Plot

Khaila Richards (Halle Berry) is an African-American woman struggling with an addiction to crack cocaine. Desperate for drugs, she places her infant son, Isaiah, in a box and leaves him in an alley behind a crack house. Khaila promises to come back for Isaiah but later passes out from a crack cocaine binge. The next day, Isaiah narrowly escapes death by a garbage truck and is rushed to the hospital, where doctors discover that he is also addicted to crack cocaine because of his mother using it while she was pregnant with him. Khaila later awakens and returns to the alley where she left Isaiah and is horrified to discover that he is gone.