Defying Gravity is a multi-nationally produced science fiction television series which first aired on August 2, 2009 on ABC and CTV and was canceled in October 2009. Set in the year 2052, the series follows eight astronauts (four women and four men) from four countries on a six-year space mission through the Solar System, during which they are monitored from Earth via a real-time communication system. The series was pitched to networks as "Grey's Anatomy in space". Thirteen episodes of the series were produced before it was cancelled, only eight of which were shown on ABC, though the full run was shown in other countries or online.

Plot

The program follows the adventures of eight astronauts on board the international spacecraft Antares, the next ambitious crewed space mission after the Mars landing. The lives of the astronauts are being constantly recorded and broadcast back to Earth both as part of an ongoing documentary and as part of mission monitoring. Despite a libido-suppressing device worn by each crew member, referred to as "HALO" for "Hormone Activated Libido Oppressors", romantic entanglements develop among some crew members. Further complicating their lives is a mysterious storage pod that contains something referred to as Beta, which is exerting an influence on their mission.