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Splice is a 2009 science fiction horror film directed by Vincenzo Natali and starring Adrien Brody, Sarah Polley, and Delphine Chanéac. The story concerns experiments in genetic engineering being done by a young scientific couple, who attempt to introduce human DNA into their work of splicing animal genes. Guillermo del Toro, Don Murphy, and Joel Silver are the executive producers of this film. Theatrically released on June 4, 2010, the film received generally positive reviews from critics but grossed just $27 million against a $30 million production budget.

Plot

Genetic engineers Clive Nicoli and Elsa Kast hope to achieve fame by splicing animal DNA to create hybrids for medical use at the company N.E.R.D. (Nucleic Exchange Research and Development). Their work previously yielded Fred, a dog-sized vermiform creature intended as a mate for their female specimen, Ginger. After successfully mating them, Clive and Elsa plan to create a human-animal hybrid that could revolutionize science. Their employers Joan Chorot and William Barlow at N.E.R.D. forbid them from doing this. Instead, they are to find and extract proteins used for commercial drug production from Fred and Ginger. Clive and Elsa, however, disobey their superiors and pursue their own agenda in secret, developing a viable prepubescent female creature. Although they had planned to terminate the hybrid before it reached full term, Elsa persuades Clive to let it live. They discover that she is aging at a vastly accelerated rate. Elsa discovers that the creature is undergoing mental development such as that of a young human child. Elsa names the creature "Dren" after the creature spells out NERD, having seen the letters on Elsa's shirt.