Splice is a 2009 science fiction horror film directed by Vincenzo Natali and starring Adrien Brody, Sarah Polley, and Delphine Chanéac. The story concerns experiments in genetic engineering being done by a young scientific couple, who attempt to introduce human DNA into their work of splicing animal genes resulting in the creation of a human–animal hybrid. Theatrically released on June 4, 2010, the film received generally positive reviews from critics, and grossed $27 million against a $30 million budget.

Plot

Genetic engineers Clive Nicoli and Elsa Kast hope to achieve fame by splicing animal DNA to create hybrids for medical use at the company N.E.R.D. (Nucleic Exchange Research and Development). Their work has yielded Fred and Ginger, two large vermiform creatures intended as mates for each other. After successfully mating them, Clive and Elsa plan to create a revolutionary human–animal hybrid. Their employers Joan Chorot and William Barlow forbid this and order them to focus on identifying and extracting proteins from Fred and Ginger for drug production.

Awards