Holmes & Watson is a 2018 mystery comedy film written and directed by Etan Cohen. The film stars Will Ferrell and John C. Reilly as the eponymous characters Sherlock Holmes and Dr. Watson, respectively; with Rebecca Hall, Rob Brydon, Kelly Macdonald, Steve Coogan and Ralph Fiennes in supporting roles. The plot follows the famed detective duo as they set out to find the culprit behind a threat at Buckingham Palace.

Plot

Sherlock Holmes is viewed as a legendary detective. Both he and his partner, Dr. John Watson, are to view the trial of Professor James Moriarty, but are attacked by a swarm of bees, temporarily waylaid by a package sent by Moriarty and brought to them by their housekeeper, Mrs. Hudson. At the trial, Holmes reveals the man accused of Moriarty's crimes is an imposter named Jacob Musgrave, who is incapable of committing the murders due to tremors in his hand caused by excessive masturbation. Despite attempts by Inspector Lestrade to convince Holmes that his deduction is incorrect, Holmes is convinced that Moriarty is currently traveling to the United States while letting Musgrave take the fall for his crimes.