The Hope Diamond Mystery is a 1921 American 15-chapter action film serial directed by Stuart Paton and featuring Grace Darmond, George Chesebro, May Yohe, and Boris Karloff. The screenplay was written by Charles Goddard and John B. Clymer, based on an autobiographical story by May Yohe (who co-stars as herself).

Plot

The curse of the legendary blue Hope Diamond on all its owners is dramatized, beginning with the gem's discovery in 17th Century India. Lord Francis Hale inherits the Hope Diamond and marries showgirl May Yohe. He later gambles away the family fortune, and May deserts him.