The Spider Woman Strikes Back is a 1946 American horror film starring Gale Sondergaard, with a running time of 59 minutes. Despite the similar title and role played by Sondergaard, the film is not a sequel to the Sherlock Holmes film The Spider Woman. In The Spider Woman, Sondergaard's character is named Adrea Spedding. This time it is Zenobia Dollard.

Plot

A young woman comes to a small rural town to serve as secretary for a blind woman, the town's wealthiest person. The town is awash in mystery owing to the inexplicable deaths of local ranchers' cattle. The young woman becomes entangled in a web of horror as she discovers that her employer, aided by the hideously deformed household servant, has used the blood of her predecessors to create a death serum when it is mixed with spider venom - and that her own blood is now being harvested at night, while she is in a drugged sleep, to continue the experiment.