Chandramukhi is a 2005 Indian Tamil-language psychological comedy horror film written and directed by P. Vasu. It is a remake of Vasu's Kannada film Apthamitra (2004) which itself was based on the Malayalam film Manichitrathazhu (1993). The film stars Rajinikanth, Prabhu and Jyothika along with an ensemble supporting cast, including Vadivelu, Nayanthara, Nassar and Sheela. It revolves around a woman who suffers from dissociative identity disorder that affects a family, and a psychiatrist who intends to solve the case while risking his life.

Plot

Dr. Saravanan, a psychiatrist, visits India on vacation. He meets up with his foster brother Senthilnathan, alias Senthil, and his wife Ganga. Senthil's mother Kasthuri, wanted Senthil to marry Priya, the daughter of his father's cousin, Kandaswamy, to reunite the two branches of the family after 30 years of separation because Senthil's father chose to marry Kasthuri instead of Akhilandeshwari, Kandaswamy's sister. Saravanan learns that Senthil had bought the Vettaiyapuram mansion, despite attempts by the local village elders to dissuade them, and moves in with them. Akhilandeshwari is jealous of Saravanan and plots to kill him with the help of her assistant Oomaiyan.