The Powerpuff Girls Movie is a 2002 American animated prequel superhero film based on the Cartoon Network animated television series The Powerpuff Girls. It was co-written and directed by series' creator Craig McCracken (in his feature-length directorial debut), co-written by Charlie Bean, Lauren Faust, Paul Rudish, and Don Shank, and stars the regular television cast of Cathy Cavadini, Tara Strong, E. G. Daily, Roger L. Jackson, Tom Kane, Tom Kenny, Jennifer Hale, and Jennifer Martin. Serving as an origin story of the titular characters, the film follows the newly created girls as they become ostracized for inadvertently destroying Townsville and assisting in Mojo Jojo's plot for world domination.

Plot

In the crime and injustice-riddled city of Townsville, Professor Utonium mixes sugar, spice and everything nice, hoping to produce the "perfect little girls" to improve Townsville. However, he accidentally breaks a flask of Chemical X, which spills onto the concoction. The experiment succeeds, producing three little girls whom the Professor names Blossom, Bubbles, and Buttercup. He also discovers that the girls have gained superpowers from the added Chemical X. Despite the girls' recklessness with their powers, they all immediately grow to love each other as a family.